" Apr 24, 2023 · Startups led by MIT mechanical engineers offer health care solutions. multi-photon 3D printing) at the nano- and microscale with favorable material properties to facilitate device behavior. Displaying 121 - 135 of 152 news articles related to Aug 28, 2020 · In work that could impact industries from pharmaceuticals to cosmetics, MIT engineers have developed a platform for the controlled delivery of drugs and more to human cells. Room E25-330 Cambridge, MA 02139-4307 Investigating the mechanism of release from polymeric delivery systems with concomitant microstructural analysis and mathematical modeling Studying applications of these systems including the development of effective long-term delivery systems for insulin, anti-cancer drugs, growth factors, gene therapy agents and vaccines Will join an interdisciplinary, creative, and highly collaborative team of scientists and engineers at MIT that uses aspects of nanotechnology, drug delivery, biological engineering, materials science, and chemistry to create innovative solutions in cancer research, imaging, catalysis, environmental bioremediation. Apr 19, 2023 · The MIT team wanted to come up with a way to perform this kind of transdermal drug delivery with a lightweight, wearable patch, which could make it easier to use for a variety of applications. Dec 11, 2020 · Bob Langer, a chemical engineer at MIT who has been investigating and developing drug delivery platforms for decades, highlights three key characteristics that could give exosomes the edge over Oct 21, 2015 · Using ultrasound waves, researchers from MIT and Massachusetts General Hospital have found a way to enable ultra-rapid delivery of drugs to the gastrointestinal tract. One key to developing this system was perfecting and calibrating a way of making liposomes of a highly uniform size and composition. Apr 11, 2024 · The human immune system is a network made up of trillions of cells that are constantly circulating throughout the body. The patch has demonstrated significantly enhanced drug penetration compared to passive diffusion and microneedling, and the team Jul 10, 2020 · While this is a more specific form of delivery compared to systemic administration of a drug through the bloodstream, many brain regions are irregular in shape. Dec 27, 2010 · Caption: Michael Cima, left, and Heejin Lee SM ’04, PhD ’09 display the drug-delivery devices they developed to help treat interstitial cystitis. K. The device is designed so that insulin can slowly seep out through pores in the drug reservoir or be released in a large burst controlled by the actuator. in Biomedical Engineering from Boston University and a Ph. Sep 28, 2022 · A new drug capsule developed at MIT can help large proteins such as insulin and small-molecule drugs be absorbed in the digestive tract. Paul Janssen Award for his groundbreaking work in designing novel drug delivery systems that can deliver medications continuously, precisely, and at controlled rates over extended periods. When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream. Feb 17, 2022 · Hillery A. Department of Chemical Engineering 77 Massachusetts Avenue, Room 66-350 Cambridge, Massachusetts 02139 MIT News; Topics; Drug delivery Topic Drug delivery. 1997; 24:345–363. Mar 9, 2009 · Furthermore, the researchers can control the rate of release by changing the density of the gel, allowing for continuous drug delivery over a specific period of time. g. “Designed to circulate through the bloodstream, these small but mighty travelers [nanoparticles] can deliver a chemotherapy drug directly to a target cancer cell without disturbing any Jun 8, 2023 · Canan Dagdeviren + co-workers report a soft, conformable embodiment of a wearable ultrasound patch for transdermal drug delivery to the skin Conformable Decoders' latest invention, cUSP, has made the front cover page of Advanced Materials' June issue — MIT Media Lab Prof. The low delivery rates, low reliability due to the dependence on mechanical moving parts in fluids, and high power consumption are among the prime limitations of an implantable drug delivery device that relies on micro-pumps. For his post-doctoral research, he transitioned to the fields of chemical and biomedical engineering in the laboratory of Professor Robert Langer at MIT where he developed a series of novel technologies for drug delivery as well as physiological sensing via the gastrointestinal tract. It is still used today. Dr. Aug 30, 2021 · A team of MIT engineers, in collaboration with scientists from Brigham and Women’s Hospital and Novo Nordisk, is working on an alternative delivery strategy that could make it much easier for patients to benefit from monoclonal antibodies and other drugs that usually have to be injected. Researchers at MIT and Brigham and Women's Hospital have developed a new drug capsule that remains in the stomach for up to two weeks after being swallowed, Brad Pentelute, Professor in the Department of Chemistry, modifies naturally occurring proteins to enhance their therapeutic properties for human medicine, focusing on the use of cysteine arylation to generate abiotic macromolecular proteins, the precision delivery of biomolecules into cells, and the development of fast flow platforms to rapidly produce polypeptides. Displaying 91 - 105 of 148 news clips related to this Jan 12, 2024 · In the West Virginia study, three people with mild Alzheimer’s received monthly doses of aducanumab, a lab-made antibody that is delivered via IV. 4 Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, United States. LNPs were later used in the mRNA vaccines for Covid-19. Researchers at MIT potentially found a way to address the difficulties of transdermal drug delivery through a new wearable patch. Koch Institute for Integrative Cancer Research at MIT. To demonstrate the potential usefulness of this device, the researchers showed that it could be used to deliver insulin in mice. This means that delivery throughout a specific brain region using a single catheter, while also limiting the spread of a given drug beyond the targeted area, is difficult. Our research has advanced fundamental understanding of transport processes in biological systems and has led to the development of new materials as well as technologies for diagnosis and treatment of various ailments including diabetes, cancer, arthritis, hemorrhage and infections, among others. Feb 13, 2024 · MIT Institute Professor Robert S. The ultrasound patch developed by MIT researchers for targeted drug delivery [Image courtesy of MIT] The team thinks the skin can enable drugs to travel directly to where they Feb 7, 2019 · Inspired by the shell of a leopard tortoise, MIT researchers have developed a self-orienting ingestible capsule that can deliver doses of medication to the stomach, writes Megan Thielking for STAT. Nov 16, 2016 · Researchers have developed a drug capsule that remains in the stomach for up to two weeks after being swallowed, gradually releasing its drug payload over time. The device that they designed consists of a patch embedded with several disc-shaped piezoelectric transducers, which can convert electric currents into Apr 8, 2024 · Speeding up drug discovery with diffusion generative models. Robert Langer explains that the material is invisible and “conforms to the skin. Jul 25, 2017 · To ensure patients receive full medicinal treatments, engineers at MIT and Brigham and Women’s Hospital have developed a new set of hydrogel-based drug delivery materials, which can live in the stomach up to nine days, slowly releasing medication. Oct 6, 2021 · MIT Alumni Association. 600 Memorial Drive Cambridge, MA 02139 617-253-8200 Aug 5, 2022 · Sustained drug delivery. Sep 14, 2017 · MIT engineers have developed a new 3-D fabrication method that can create a new type of drug-carrying particle that could allow several doses of a drug or vaccine to be delivered over an extended time period with just one injection. Jan 8, 2024 · An MIT study finds that when a liquid crystal slowly flows, its normally orderly microstructures (bottom-left illustration) spontaneously rotate and twist to form macro-scale, tiger-like stripes. Langer was recently honored with the 2023 Dr. . Ultrasound-induced transdermal drug delivery (sonophoresis) has long lingered in the by-lanes of academic and industrial research, and has failed to attain tan… Overview ‹ conformable Ultrasound Patch (cUSP) For Cavitation-Enhanced Transdermal Drug Delivery — MIT Media Lab May 24, 2012 · MIT-engineered device injects drug without needles, delivering a high-velocity jet of liquid that breaches the skin at the speed of sound. Apr 11, 2023 · The study of drug delivery in plants using silk microneedles expanded upon previous research supervised by Marelli. in Biomedical Engineering from Brown University. To boost delivery to the nucleus, researchers can affix cell-penetrating peptides (CPPs) to the drug, thereby helping it cross the cell and nuclear membranes to reach its target. Eventually, Alnylam developed the first lipid nanoparticles (LNPs) that could be used to encase RNA and deliver it into patient cells. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. Displaying 31 - 45 of 146 news articles related to this Mar 6, 2024 · “Understanding how the drug delivery vehicle can enhance an adjuvant immune response is something that could be very helpful in designing new vaccines,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research and one of the senior authors of the new study. Measuring drug response Apr 26, 2024 · In this study, the researchers focused on a drug called 5-fluorouracil, which is used to treat colorectal cancers, among others. Displaying 121 - 135 of 148 news clips related to this Apr 26, 2019 · MIT engineers have designed tiny robots that can help drug-delivery nanoparticles push their way out of the bloodstream and into a tumor or another disease site. doi: 10. Her postdoctoral training was with Institute Prof. org/ibioseminars/robert-langer-part-1. “If we’re able to deliver large molecules orally, it would not only change drug delivery but also drug discovery,” says Prof. “Our system is an oil-based system gel, which makes it compatible with most drugs,” says visiting scientist Ameya Kirtane. 107, Dec. D. May 23, 2024 · Early on, Alnylam collaborated with MIT drug delivery expert and Institute Professor Bob Langer. The capsule has a robotic cap that spins and tunnels through the mucus barrier when it reaches the small intestine, allowing drugs carried by the capsule to pass into cells lining the intestine. “Anthrax toxin is a professional at delivering large enzymes into cells,” says Bradley Pentelute, the Pfizer-Laubauch Career Development Assistant Professor of Chemistry at MIT. Jun 23, 2020 · While this is a more specific form of delivery compared to systemic administration of a drug through the bloodstream, many brain regions are irregular in shape. Using this model, the researchers were able to achieve a six-fold increase in the percentage of microparticles they could successfully inject. Our laboratory integrates material science, chemistry, imaging and biology in the design of smart materials and medical devices to improve human health. In 2019, the researchers designed a capsule that, after being swallowed, can place solid drugs, such as insulin, into the lining of the stomach. Drug Delivery Rev. [Image from Felice Frankel/MIT] Researchers at the Massachusetts Institute of Technology (MIT) developed a new drug capsule with a robotic cap for improved drug delivery. In such cases, it would be useful to have a selective drug or substance removal system. 2016, pp. Examples include removal of heparin, bilirubin, and cholesterol. historical perspective of biomaterials research for drug delivery, along with the challenges and opportunities for biomaterials in three emerging areas of drug delivery: (i) nucleic acid delivery, (ii) “smart” bioresponsive materials for controlled drug delivery, and (iii) biomaterials to improve biocompatibility in drug delivery. MIT researchers employ machine learning to find powerful peptides that could improve a gene therapy drug for Duchenne muscular dystrophy. MIT News; Topics; Drug delivery Topic Drug delivery. The cellular network orchestrates interactions with every organ and tissue to carry out an impossibly long list of functions that scientists are still working to understand. Using a human tissue model that replicates the blood-brain barrier, they showed the particles could get into tumors and kill glioblastoma cells. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Engineers led by Sangeeta Bhatia have designed tiny robots that use magnetism to push drug-delivery nanoparticles out of blood vessels and into diseased tissue. May 22, 2024 · Immune action at a distance. Drug delivery is the science and engineering of converting potent drugs into beneficial therapies. drug delivery, providing for active delivery of fluids from single or multiple reservoirs. Prof. The team, led by Shuguang Zhang, associate director of MIT's Center for Biomedical Engineering, reports its findings in the March 9 online edition of the Proceedings of the This online course offers a unique way for professionals to learn from leading Harvard Medical School faculty about cutting-edge drug delivery systems and approaches that can be used in the treatment and prevention of disease. Often, this path starts with innovation from academic collaborations amongst biologists, chemists, and engineers, followed by the formation of a start-up company driving clinical translation and approval. The Mitragotri group is engaged in the research field of drug delivery and biomaterials. Sep 14, 2012 · Ultrasound transdermal drug delivery could also offer a noninvasive way for diabetics to control their blood sugar levels, through short- or long-term delivery of insulin, the researchers say. edu Biomaterials, Composites, Electronic, Photonic, and Magnetic Jan 24, 2018 · The biocompatible, remote controlled MiNDS permits dynamic neural adjustment with pinpoint spatial resolution and cell-type specificity. ” Advanced Drug Delivery Reviews, vol. Read full story → Jan 31, 2022 · Oral drug delivery For several years, Langer’s and Traverso’s labs have been developing novel ways to deliver drugs to the gastrointestinal tract. Displaying 1 - 15 of 149 news articles related to this Apr 11, 2023 · A microneedle-based drug delivery technique for plants that can deliver controlled amounts of agrochemicals to plant tissues could be used to improve crop quality and disease management. Jan 24, 2023 · 3 Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, Massachusetts 02139, United States. Apr 24, 2024 · This approach could help to compensate for differences in drug pharmacokinetics caused by body composition, genetic makeup, chemotherapy-induced toxicity of the organs that metabolize the drugs, interactions with other medications being taken and foods consumed, and circadian fluctuations in the enzymes responsible for breaking down chemotherapy drugs, the researchers say. 367–92. Jaklenec received a B. Read full story → Over the past 50 years, drug delivery breakthroughs have enabled the approval of several important medicines. Robert Langer at MIT, where her research focused on drug delivery of biologics (among other projects). The simple approach creates capsules containing nanoscale droplets loaded with an active ingredient. In 1987, Langer founded Enzytech alongside fellow MIT professor Alexander Klibanov. This type of drug delivery, developed at MIT and Brigham and Women’s Hospital, could eliminate lengthy drug regimens that require repeated doses, which would help to overcome one of the major obstacles to treating diseases such as Jul 13, 2022 · This type of drug delivery could also be useful for treating diseases such as cancer. January 27, 2023. Companies founded by MechE faculty and alumni solve a variety of health care challenges, from better drug delivery to robotic surgery. Following ultrasound treatment, improved permeability can last up to 24 hours, allowing for delivery of insulin or other drugs over an extended period of Jul 15, 2011 · 29 May 2021: Sachin's review on the development and delivery of TLR agonists is now available as an open access paper in Advanced Drug Delivery Reviews. The drug is typically infused over a 46-hour period, and the dosage is determined using a formula based on the patient’s height and weight, which gives the estimated body surface area. Displaying 91 - 105 of 151 news articles related to this May 9, 2016 · A new material developed by MIT researchers could assist with everything from tightening wrinkles to delivering medication to the skin, reports Enjoli Francis for ABC News. “Designed to circulate through the bloodstream, these small but mighty travelers [nanoparticles] can deliver a chemotherapy drug directly to a target cancer cell without disturbing any healthy cells along the way,” writes Migliori. A new way to deliver drugs more efficiently | MIT News | Massachusetts Institute of Technology May 13, 2024 · MIT researchers are developing targeted drug delivery through the use of nanoparticles to aid in cancer treatment, reports Simone Migliori for Boston Magazine. Tissue-responsive biomaterials, drug-delivery devices, nano-theranostics for cancer therapy and cardiovascular diseases, nanocomposite materials for orthopedics. M. Oct 7, 2019 · MIT engineers designed a drug capsule that can carry insulin or other protein drugs and protect them from the harsh environment of the gastrointestinal tract. Feb 17, 2015 · http://www. Credit: Courtesy of the researchers Aug 10, 2021 · “But there’s a problem with PMO by itself. We are investigating how smart degradable polymer-based controlled drug delivery systems can be used to obtain targeted, sustained and tunable release kinetics. Apr 1, 2021 · Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off May 11, 2023 · By Anne Trafton | MIT News Office. August 10, 2021. . Macfarlane | Lab Website DEPARTMENT OF MATERIALS SCIENCE AND ENGINEERING (617) 253-3300, rmacfarl@mit. MIT researchers built DiffDock, a model that may one day be able to find new drugs faster than traditional methods and reduce the potential for adverse side effects. The lab’s interest in drug delivery systems has extended to situations where drugs may serve a potentially useful purpose and then cause toxicity. Aug 10, 2021 · “But there’s a problem with PMO by itself. 1016/S0169-409X(96)00496-6. Farah, Shady, et al. The work could help overcome a major obstacle to delivering drugs via nanoparticles. The study of drug delivery in plants using silk microneedles expanded upon previous research supervised by Marelli. The original idea was conceived by SMART and MIT: Marelli, Cao, and Professor Nam-Hai Chua, co-lead principal investigator at DiSTAP. Nov 28, 2023 · MIT researchers find that core-shell structures made of hydrogel could enable more efficient drug uptake by the body, as well as controlled release of multiple drugs from one pill. MIT Institute for Medical Engineering & Science 77 Massachusetts Ave. ibiology. Langer (right) and Michael J. Professor Robert J. Image courtesy of the MIT BioInstrumentation Lab The speed of the coil and the velocity imparted to the drug can be controlled by the amount of current applied; the MIT team generated pressure profiles that A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs. “Physical and Mechanical Properties of PLA, and Their Functions in Widespread Applications — A Comprehensive Review. Robert Langer. Dane Wittrup, Ph. [Google Scholar] He returned to MIT in 2009 to join the faculty in the Department of Biological Engineering, where he runs an interdisciplinary research group focused on the targeted delivery of therapeutic nucleic acids and vaccines, phenotypic profiling of neuronal circuits involved in psychiatric disease, and engineering nucleic acid materials for highly Jun 1, 2022 · MIT researchers developed drug-carrying nanoparticles that appear to get into the brain more efficiently than drugs given on their own. Adv. Dubbs Professor of Chemical Engineering and Bioengineering Associate Director, Koch Institute for Integrative Cancer Research The US-Japan Symposium on Drug Delivery Systems offers presentations by researchers from a number of disciplines, from the life sciences to engineering, who will address a range of topics including peptide and protein delivery, gene delivery, cell delivery, vaccines, transdermals, pulmonary delivery, new materials, and other subjects, from Jul 12, 2022 · MIT researchers developed a geometric deep learning model that is more accurate and over 1,000 times faster at finding potential drug-like molecules than the fastest state-of-the-art computational models, reducing the chances and costs of failures in an industry where 90 percent of drug candidates fail clinical trials. Awesome work Sachin! Awesome work Sachin! Click on the image below to check out the paper. The Mitragotri Laboratory for Drug Delivery is developing innovative technologies to tackle some of the major problems in human health. Cima holds the device built for humans; Lee's is sized for a rabbit. Kevin McHugh's primary research interest is in the development of biomaterial microdevices for drug delivery and tissue engineering. You can use it to deliver a drug, if you want, and it's mechanically quite strong. 5 Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States. Together, they Jun 29, 2022 · Machine learning discovers new sequences to boost drug delivery . Displaying 46 - 60 of 152 news articles related to this breakthrough in drug delivery, in 1996, the Food and Drug Administration authorized Langer and Brem’s Gliadel wafer to treat glioblastoma multiforme which is the deadliest type of brain cancer. htmlTalk Overview: The traditional way of taking a drug, such as a pill or injection, often result MIT News; Topics; Drug delivery Topic Drug delivery. Jul 20, 2023 · MIT’s transdermal drug delivery patch. He completed PhD studies as a fellow in the Neurosciences Program at Stanford University. MIT and MGH researchers design a local, gel-based drug-delivery platform that may provoke a system-wide immune response to metastatic tumors. This approach could make it easier to deliver drugs to patients suffering from GI disorders such as inflammatory bowel disease, ulcerative colitis, and Crohn’s disease. Ed Boyden completed his undergraduate degrees in Physics and Electrical Engineering and Computer Sciences and a Master of Engineering at MIT. November 30, 2023. Cima speak in the Cima Lab at the David H. The skin is an appealing route for drug delivery because it allows drugs to go directly to the site where they’re needed, which could be useful for wound healing, pain relief, or other medical and cosmetic applications. The magnetic microrobots could help to overcome one of the biggest obstacles to delivering drugs with nanoparticles: getting them to exit blood vessels and accumulate in the right place. Feb 16, 2012 · Caption: Professors Robert S. Download RSS feed: News Articles / In the Media / Audio. Read full story. Supramolecular lipidic drug delivery systems: From laboratory to clinic A review of the recently introduced commercial liposomal and lipid-based formulations of amphotericin B. Jan 24, 2018 · Because the brain is so structurally complex, new accurate ways to deliver drugs or related therapeutic agents locally are urgently needed,” says Ann Graybiel, an MIT Institute Professor and a member of MIT’s McGovern Institute for Brain Research, who is also an author of the paper. Jul 21, 2022 · MIT researchers are developing targeted drug delivery through the use of nanoparticles to aid in cancer treatment, reports Simone Migliori for Boston Magazine. Jul 8, 2020 · MIT researchers have developed a computational model that can help them improve the injectability of drug-delivery microparticles and prevent clogging. P. His laboratory combines cutting edge manufacturing techniques (e. Investigating the mechanism of release from polymeric delivery systems with concomitant microstructural analysis and mathematical modeling Studying applications of these systems including the development of effective long-term delivery systems for insulin, anti-cancer drugs, growth factors, gene therapy agents and vaccines Apr 28, 2023 · MIT researchers have developed a wearable ultrasonic patch that enables efficient drug delivery through the skin, with potential applications in wound healing, pain relief, and various medical and cosmetic treatments. S. May 27, 2022 · FiercePharma’s Nick Paul Taylor writes about a new drug delivery gel developed by researchers at MIT and Brigham and Women’s Hospital. With dual chemical delivery channels and an electrode, microfabricated MiNDS can chemically modulate local neuronal activity and related behavioral changes in animal subjects while simultaneously recording neural activity to enable feedback control. edu Drug-delivery, Hydrogels, Biopolymers, Nanoparticles, Semiconducting polymers, Organometallic polymers, Photoactive polymers. Langer and Cima work together in biotechnology and have developed a new implantable medical device which allows repeated wireless drug delivery in lieu of injections. The work was developed at SMART, MIT, and Temasek Life Sciences Laboratory. C. Aug 19, 2019 · And the system is broadly applicable for drug delivery: “we can encapsulate any water-soluble drug,” and with some adaptations, other drugs as well, she says. It’s not very good at entering cells,” says Carly Schissel, a PhD candidate in MIT’s Department of Chemistry. The discovery could open new ways to design structured liquids for drug delivery and optical sensing. In a 2020 Science Translational Medicine study, the researchers published a paper in which they showed that they could deliver drugs that stimulate the STING pathway, which promotes immune responses in the environment surrounding a tumor, in several mouse (617) 253-1819, jaj2109@mit. This drug, first approved in 2021, helps clear However, the means by which to attain ideal release kinetics, targeting, and cell penetration remain elusive. aq xk ho ot sm lb xr uw oc li