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The amount of HIV virus in your blood (viral load) is measured to see how well treatment is working. Once people get HIV, they have it for life. By sharing a contaminated needle, such as through illicit drug use. HIV attacks and destroys the infection-fighting CD4 cells ( CD4 T lymphocyte) of the immune system. Swollen lymph glands. As those names imply, infection with FIV weakens a cat’s immune system, which makes it much more likely that they’ll come down with bacterial infections, certain types of cancer, autoimmune Jan 11, 2021 · Instead, the virus just gets broken down and digested in the mosquito’s stomach. Symptoms of AIDS can include: Rapid weight loss; Recurring fever or profuse night sweats; Extreme and Herpes simplex – This virus causes genital herpes, which are painful blisters in the genital area, or cold sores. HIV may not show symptoms initially. Jan 11, 2023 · HIV is a virus that weakens your immune system. The first part would involve drugs that make virus cells Jun 30, 2023 · The virus reproduces rapidly in the body, causing severe flu-like symptoms. But there is a global commitment to stopping new HIV infections and ensuring that everyone with HIV has access to HIV treatment. AIDS is the most advanced stage of HIV (human immunodeficiency virus). However, ARC patients' symptoms are often less May 16, 2024 · There is no evidence that COVID-19 vaccines interfere with ART to treat HIV or PrEP to prevent HIV. FIV is relatively uncommon, but it can have serious impacts on a cat’s health and well-being. Symptoms of HIV infection kissing. Your immune system helps defend you against infection and cancer. HIV can be spread through unprotected sexual intercourse; while sharing needles and syringes; or from mother to child Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer are considered to be AIDS-defining cancers. Feline Immunodeficiency Virus (FIV) is commonly known as Feline AIDS because of its similarities to Human Immunodeficiency Virus (HIV). May 21, 2023 · Each drug fights the virus in your body in a slightly different way. Apr 22, 2024 · In 2022, PWID accounted for 7% (2,300) of the 31,800 estimated new HIV infections. It may cause AIDS after you’ve been infected for several years and it’s weakened your immune system. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy Jun 21, 2023 · This means they aren’t always spread from person to person. Testing is recommended as a part of routine healthcare. HIV lies dormant inside a small number of cells in the body, resulting in viral reservoirs. The loss of these cells makes it hard for your body to fight off infections and certain HIV-related cancers. 2: Chronic HIV: Chronic and persistent herpes simplex virus (HSV) is an AIDS-defining condition. It's caused by the human immunodeficiency virus, also called HIV. The capsid is the container for the virus’s genetic material. If a person has HIV and is not on HIV treatment, the virus will weaken the body’s immune system and the person will progress to AIDS. Getting tested and starting treatment early gives you the best chance of living a long life. HIV is not spread through casual contact such as sharing Nov 1, 2023 · The AIDS epidemic began in the United States in the 1980s. If you have questions about getting COVID-19 vaccine and whether it is right for you, talk to your health care provider. That makes children with HIV more vulnerable to infections and disease. What is AIDS? AIDS stands for acquired immunodeficiency syndrome. In a photograph from 1983 displayed here, a female CDC research chemist conducts tests on biological fluids from HIV/AIDS and Pregnant Australian Women [ edit] By the end of 2021, there were estimated to be 3,360 women living with HIV, or 12% of all people living with HIV. This is the late stage of HIV infection. Upon infection with HIV, a person's immune system kills off nearly all of the virus and Mar 14, 2024 · HIV stands for human immunodeficiency virus. Now, follow each stage in the HIV life cycle as HIV attacks a CD4 cell and uses the machinery of Nov 28, 2023 · These include drugs that eliminate the risk of parent-to-child transmission; antiretroviral therapy, which by suppressing the virus, both protects the infected person from severe illness and death What are HIV and AIDS? Human immunodeficiency virus (HIV) is a virus that affects your immune system. have it by age 40, but people of any age can get it. Nov 15, 2023 · The Global HIV and AIDS Epidemic. Scientists have argued about the origin of the AIDS epidemic since it surfaced in 1981, but this much is widely accepted today: Sometime around 1931, HIV-1, the main virus driving the epidemic, likely entered humans from chimpanzees, which are infected with a related virus called SIVcpz. Approximately 86 million AIDS (acquired immune deficiency syndrome) is the name used to describe a number of potentially life-threatening infections and illnesses that happen when your immune system has been severely damaged by the HIV virus. May 21, 2023 · HIV and AIDS are related, but they’re not the same. Over time, HIV wears down the immune system by destroying the CD4 (T) cells that fight disease and infection. Women who inject drugs accounted for 3% (1,000) of estimated new HIV infections. Within the CD4 cell, HIV replicates and in turn, damages and destroys the cell. Kaposi sarcoma (KS) develops from the cells that line lymph or blood vessels. 1-8 Despite this shedding of infected blood or exudate, saliva of infected individuals usually contains only noninfectious May 31, 2024 · HIV stands for human immunodeficiency virus. gov Timeline reflects the history of the domestic HIV/AIDS epidemic from the first reported cases in 1981 to the present—where advances in HIV prevention, care, and treatment offer hope for a long, healthy life to people who are living with, or at risk for, HIV and AIDS. Like many STDs, AIDS symptoms in women are quite similar to the symptoms of AIDS in all genders. This puts you at risk for other infections and diseases. This reduction of transmission has become a popular use of antiretroviral therapy for HIV-positive individuals with an HIV-negative partner. It is the final stage of infection with HIV. If you have HIV and you are not on HIV treatment, eventually the virus will weaken your body’s immune system and you will progress to AIDS (acquired immunodeficiency syndrome). 4 million lives worldwide (as of 2022). Untreated HIV usually leads to acquired immunodeficiency syndrome (AIDS) within 10 years. Last updated 2021 HIV (Human Immunodeficiency Virus) is composed of two strands of RNA, 15 types of viral proteins, and a few proteins from the last host cell it infected, all surrounded by a lipid bilayer membrane. Painful, blistering rash: It could be shingles if you’ve ever had chickenpox -- the same HIV/AIDS. Early HIV symptoms are called acute retroviral syndrome or acute HIV infection. Together, these molecules allow the virus to infect cells of the immune system and force them to build new copies of the virus. In CDC’s immunology lab, scientists began working with AIDS specimens as early as July 1981 to understand how the immune systems of young, healthy men were so compromised by the mystery illness. By the late 1980s it had become a public health crisis. We dispel the myths surrounding HIV and AIDS and provide research-backed information about what life is like, including symptoms, treatments, and more. Since then, advances in HIV treatment has turned it from a deadly infection to a lifelong condition that can be managed. During this early period, HIV is present in large amounts in genital fluids and in blood and can be passed to others. When taken as prescribed, HIV medicine can make the amount of virus in your body ( viral load) so low that a test can't detect it ( undetectable viral load ). How are HIV and AIDS treated? The most effective treatment for HIV is antiretroviral therapy (ART). These are a type of white blood cells that fight infection. HIV weakens your immune system by destroying your T-cells until you are unable to fight off even minor illnesses. For this reason, NIAID invests in basic and clinical research aimed at developing a safe, affordable and scalable cure for HIV and AIDS. But many of them are. . Taking these medicines can reduce the amount of virus in your body and help you The Duesberg hypothesis is the claim that AIDS is not caused by HIV, but instead that AIDS is caused by noninfectious factors such as recreational and pharmaceutical drug use and that HIV is merely a harmless passenger virus. To understand each stage in the HIV life cycle, it helps to first imagine what HIV looks like. With proper care, cats with FIV can live many years and usually can share a household Oct 19, 2020 · Certain COVID-19 vaccine candidates could increase susceptibility to HIV, warns a group of researchers who in 2007 learned that an experimental HIV vaccine had raised in some people the risk for infection with the AIDS virus. These concerns have percolated in the background of the race for a vaccine to stem the coronavirus pandemic, but now the The human immunodeficiency virus (HIV) is a type of virus called a retrovirus. gov or call 1-800-232-0233 to find a COVID-19 vaccine near you. View Larger Download. Dec 1, 2021 · The minimal and optimal criteria for an acceptable target product profile for an HIV cure, including the duration and level of virus control off ART, has recently been developed and published by May 21, 2023 · AIDS dementia complex is caused by the HIV virus itself, not by the opportunistic infections that occur commonly in advanced HIV. AIDS is the most advanced stage of HIV infection. Some HIV stands for human immunodeficiency virus. A mosquito’s feeding Human immunodeficiency virus (HIV) is a virus that attacks the body's immune system. The HIV virus actively multiplies, infects and kills cells of the immune system called CD4+T cells, which are the immune system's key infection fighters. HIV and the syndrome it causes, AIDS, began spreading in the United States in the early 1980s. HIV damages the immune system so that the body is less able to fight infection and disease. Oral yeast infection, also called thrush. Each molecule in the Sep 20, 2022 · A typical initial HIV regimen includes 3 HIV medications from a minimum of 2 drug classes. Men who inject drugs accounted for 4% (1,300) of estimated new HIV infections. Jun 14, 2021 · Pride. In the United States, the most common type of KS is related to infection with both the human herpes virus 8 (HHV-8) and HIV virus. Ultimately, people infected with HIV can become very sick from opportunistic infections Prevention of HIV/AIDS. It’s possible to also experience a variety of symptoms when the virus is transmitted. The human immunodeficiency virus, or HIV Dec 11, 2023 · The person-to-person spread of human immunodeficiency virus (HIV) is called HIV transmission. in the early 1980s. People can get or transmit HIV only through specific activities, such as sex or injection drug use. But proper medical care can control the virus. Without treatment, HIV can gradually destroy the immune system, causing health ELISA: The First HIV Blood Test. These cells help your body stay healthy by fighting off disease. [1] The hypothesis was popularized by Peter Duesberg, a professor of biology at University of California, Berkeley, from Jul 26, 2023 · HIV, the virus that causes AIDS (see box), has become one of the world’s most serious health and development challenges since the first cases were reported in 1981. [61] In 2013, the median age of diagnosis for women was 30 years of age. When it comes to HIV transmission, it’s important to know what Apr 11, 2024 · HIV, or human immunodeficiency virus, is the virus that causes acquired immune deficiency syndrome (AIDS). In 1 day ago · July 2, 2024 — A major challenge in developing a vaccine for HIV is that the virus mutates fast -- very fast. HIV, or human immunodeficiency virus, is the virus that causes AIDS (acquired immunodeficiency syndrome) and can be transmitted during sexual intercourse; by sharing syringes; or perinatally during pregnancy, childbirth or breastfeeding. HIV is a lentivirus (literally meaning “slow virus”; a member of the retrovirus family) that slowly attacks and destroys the immune system, the body’s defense against infection, leaving an individual vulnerable to a variety of other Aug 3, 2022 · AIDS, the disease caused by HIV, first emerged in the U. Once HIV enters the body, it infects large numbers of CD4+ cells and rapidly spreads throughout the body and into many organ systems. If HIV isn't treated, it can take years before it weakens the immune system enough to become AIDS. Researchers estimate that some time in the early 20th century, a form of Simian immunodeficiency virus found in chimpanzees (SIVcpz) first entered humans in Central Africa and began circulating in Léopoldville (modern-day Kinshasa) by the 1920s. After starting HIV treatment, the goal is to have a viral load so low that it doesn't show up on the test, called undetectable. [3] Nov 15, 2023 · The Global HIV and AIDS Epidemic. ART is recommended for everyone who has HIV. HIV/AIDS. Its presence Oct 7, 2015 · But in 1989, NIH researchers made several major discoveries about how the human immunodeficiency virus (HIV) destroys the body’s immune system and ultimately leads to full-blown AIDS. The successes of antiretroviral therapy have reduced HUMAN immunodeficiency virus (HIV) transmission from oral secretions of the millions of HIV-viremic individuals during kissing, dental treatment, biting, and aerosolization is a rare event, even when infectious HIV is shed into the oral cavity by infected blood or exudate. However, HIV was propagating in the country before that. Feb 23, 2023 · HIV is a virus, and AIDS is the condition the virus may cause. HIV attacks the immune system by entering and destroying CD4+ T cells, a type of white blood cell that is vital to fighting off infection. HIV is a manageable chronic condition. Many people involved in HIV cure research acknowledge Apr 11, 2024 · It’s also known as a sterilizing cure or complete cure. A HIV-fertőzés okozza az AIDS (szerzett immunhiányos szindróma) betegséget. Antiretroviral medicines slow the rate at which the virus grows. Jul 13, 2017 · HIV and AIDS began spreading among humans in the 1920s and became a public health crisis by the 1980s, before the first effective treatments emerged. 6 days ago · AIDS, transmissible disease of the immune system caused by the human immunodeficiency virus ( HIV ). There is currently no evidence that FIV can infect or cause disease in humans. While AIDS cannot be transmitted from 1 person to another, the HIV virus can. HIV, the virus that causes AIDS, is one of the world’s most serious public health challenges. With treatment, people living with HIV can have long and healthy lives. Different combinations of HIV medicines work for different people, so the medicine you take will be individual to you. Fatigue. HIV is a virus that transmits via The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. HIV (human immunodeficiency virus) is a virus that attacks the body's immune system. Although a person initially becomes infected with one or a few HIV strains, the Apr 20, 2023 · HIV — short for human immunodeficiency virus — is a virus that affects the immune system — more specifically, white blood cells known as CD4 cells, or T-cells, that are part of the immune A virus is a small infectious organism that can only replicate inside living cells of other organisms; in HIV’s case, human immune cells. May 1, 2024 · FIV (feline immunodeficiency virus) is the virus that can eventually progress to feline acquired immunodeficiency syndrome (similar to AIDS in humans ). [1] There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. ART cannot cure HIV, but HIV medicines help people with HIV live longer, healthier lives. CMV spreads easily through an infected person's saliva or other body fluids. having oral sex with a condom or dental dam. Your immune system is a complex network of organs, tissues and cells, called white blood The HIV. There is no cure for HIV, but treatment with HIV medicines (called antiretroviral therapy or ART) can slow or prevent HIV from advancing from one stage to the next. The latest statistics on HIV around the world from UNAIDS Exit Disclaimer include: Mar 26, 2019 · ARC is a condition caused by the AIDS virus in which the patient tests positive for AIDS infection and has a specific set of clinical symptoms. If treatment is stopped, these reservoirs can become active and start producing HIV. Without effective treatment of a combination of antiretroviral (ARV) drugs, the immune system will become A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. This greatly reduces your chances of opportunistic infection and other HIV -related complications. Learn how the human immunodeficiency virus (HIV) causes AIDS, where HIV may have originated, and how AIDS has become one of the worst pandemics in modern history. Research shows that a combination, or "cocktail," of drugs is the best way to control HIV and lower the chances that the virus Aug 26, 2021 · When untreated, an STI can become a disease. Oct 9, 2023 · Medications will help control the virus, keep your infection from becoming AIDS, and help you stay healthy and live longer. Weight loss. Medicine resistance. HIV is a retrovirus that infects cells of the human immune system (mainly CD4-positive T-cells and macrophages—key components of the cellular immune system) and destroys or impairs their function. Diarrhea. Watch a video to learn about the approaches NIAID is taking to achieve a cure for HIV. You can have HIV without any symptoms. Initially the U. As the virus continues to multiply and destroy immune cells, you may get mild infections or long-term symptoms such as: Fever. Mar 7, 2024 · Cytomegalovirus is a common virus. The Age of AIDS - The extraordinary story of a virus's spread Antiretroviral therapy stops HIV from replicating (making copies of itself), but effective treatment does not completely eliminate the virus from the body. We do not know exactly how the virus damages brain cells. Many people with HIV get flu-like symptoms of it early on, but some people don't. Other examples of STDs are chlamydia, gonorrhea, human papillomavirus (HPV) infection, and syphilis. [2] A vírus leggyakrabban szexuális úton terjed és egyaránt megtalálható a Aug 10, 2021 · However, even if people with HIV feel healthy, the virus is still affecting their bodies. Human papilloma virus (HPV) – This condition is considered the most common sexually transmitted disease (STD) in the United States. The latest statistics on HIV around the world from UNAIDS Exit Disclaimer include: Although FIV is similar to human immunodeficiency virus (HIV) and causes a feline disease similar to acquired immune deficiency syndrome (AIDS) in humans, it is a highly species-specific virus that infects only felines. HIV harms your immune system by destroying a type of white blood cell that helps your body fight infection. It causes AIDS (acquired immunodeficiency syndrome), which is life-threatening. HIV can be transmitted only in certain body fluids from a person who has HIV. As soon as HIV enters the body, it begins to disable or destroy these cells, even when you are not experiencing any symptoms. Common examples of contagious viral diseases include the flu, the common cold, HIV, and herpes. There's currently no cure for HIV, but there are May 22, 2023 · The virus can grow out of control in people with HIV, so see a dermatologist for treatment right away. Kaposi sarcoma. Rash. S. This is a combination of several medicines that aims to control the amount of virus in your body. Jun 6, 2022 · Human immunodeficiency virus (HIV) is the virus that causes acquired immune deficiency syndrome (AIDS). Usually, people who have just been diagnosed with HIV take between 1 and 4 pills a day. The destruction of these cells leaves people with HIV vulnerable to other pathogens and complications. There is currently no effective cure. HIV is a virus. Jun 15, 2022 · Stage 3: AIDS. HIV is called an immunodeficiency virus because it weakens (causes deficiency) of your immune system. However, the research, development, and widespread availability of highly active antiretroviral therapies (ARTs) have helped contain the HIV pandemic HIV/AIDS. May 6, 2024 · The human immunodeficiency virus (HIV) was first identified in 1983 and has since claimed approximately 40. However, if left untreated, it can cause a weakened immune system or acquired immune deficiency syndrome (AIDS). [1] [2] [3] This gave rise to the pandemic form of HIV The three stages of HIV infection are (1) acute HIV infection, (2) chronic HIV infection, and (3) acquired immunodeficiency syndrome (AIDS). [1] Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. It gradually destroys a type of immune cell known as CD4. ART is recommended for everyone with HIV, and people with HIV should start ART as soon as possible after diagnosis, even on that same day. In order to understand how HIV and AIDS are connected we need to take a closer look at how the immune system works. Other types of Mar 15, 2021 · HIV is a virus that attacks the immune system. Once it can no longer be measured it's Visna-maedi virus. Swollen lymph glands, which are often one of the first symptoms of HIV infection. People with HIV may have symptoms in the very beginning of their infection, like swollen glands, fever, headaches, and muscle soreness. The virus can be passed in only certain ways: During sex with a person infected with HIV. May 21, 2024 · The virus is a master of evasion, dodging the immune system by coating itself in sugars that resemble those made by the body, Related: We could end the AIDS epidemic in less than a decade Overview. HIV may Jun 16, 2022 · How Do You Get AIDS? You can’t “catch” AIDS, which stands for acquired immunodeficiency syndrome. Not everyone who has Oct 12, 2021 · AIDS was first identified in the United States in 1981. Since the first AIDS cases were reported in 1981, HIV/AIDS has been one of humanity’s deadliest May 31, 2019 · The virus that causes AIDS is called HIV, or human immunodeficiency virus. [ 1, 2] Apr 24, 2020 · HIV compromises the immune system and may result in opportunistic infections that cause many symptoms. ART involves taking a combination of HIV medicines (called an HIV treatment regimen) every day. The loss of CD4 cells makes it difficult for the body to fight off infections, illnesses, and certain cancers. Sore joints, muscles or throat. Oct 19, 2023 · AIDS 101. using clean sex toys. The extraordinary story of a virus's spread -- infecting over 70 million people -- and how the world has been unable to stop it. These activities are “lower risk” — they’ve only caused a few reported cases of HIV (out of millions): "French” or deep kissing (if the person with HIV has sores or bleeding in their mouth) vaginal sex with a condom and/or PrEP. There is no cure for HIV/AIDS, but antiretroviral (ARV) prescription medications allow people with HIV to live Aug 24, 2022 · The key with Johnson and others has been preventing their incurable disease from progressing into AIDS. HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. Jul 13, 2023 · GENEVA, 13 July 2023—A new report released today by UNAIDS shows that there is a clear path that ends AIDS. It can cause warts on the anus Apr 19, 2019 · The Truth About Feline AIDS. Severe conditions are more common in the advanced stage of AIDS. It’s transferred through bodily fluids like semen, vaginal fluids, and blood. HIV, which is the virus that may lead to AIDS, remains a global epidemic today. It harms your immune system by destroying CD4 cells. In 1996, NIH-funded scientists discovered a new class of drugs, known as protease inhibitors. This number is staggering, and if left unchecked, HIV could become a global health crisis. People on ART take a combination of HIV medicines called an HIV treatment regimen. Jan 11, 2023 · Tiredness. Over half of adults in the U. Aug 16, 2021 · The treatment for HIV is called antiretroviral therapy (ART). Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and during the birth process or via human milk (vertical transmission). Protecting yourself from HIV begins with understanding how the virus is spread. Although this treatment is not curative, it can provide longer lives for patients and reduce HIV transmission. The reasons for acquiring the HIV blood test is spread across three circumstances. HIV is a sexually transmitted infection, but it can progress to a disease called acquired immunodeficiency syndrome (AIDS) when HIV infection is untreated with HIV medicines. [1] Az AIDS lefolyása során az immunrendszer fokozatosan, általában 9-11 év alatt leépül és a fellépő opportunista fertőzések, tumorok a beteg halálához vezetnek. They’ll also lower your risk of spreading HIV to other people Feb 9, 2024 · Acquired immunodeficiency syndrome (AIDS), is an ongoing, also called chronic, condition. May 5, 2023 · HIV/AIDS. What is HIV? The human immunodeficiency virus (HIV) targets cells of the immune system, called CD4 cells, which help the body respond to infection. In fact, many people with HIV live for years without developing AIDS. This path will also help prepare for and tackle future pandemics and advance progress towards achieving the Sustainable Development Goals. AIDS, or acquired immunodeficiency syndrome, is the final stage of HIV, or human immunodeficiency virus infection, in which CD4 white blood cells, or T-cells of the body's immune system, are considerably infected and destroyed. Feb 9, 2024 · This test measures the amount of virus in your blood. From HIV mother to child either during pregnancy, labor or breastfeeding. An HIV infection doesn’t necessarily progress to stage 3. About 37 million people around the world are currently living with AIDS. Jan 24, 2024 · Overview. More-serious or longer lasting symptoms See also: Timeline of early HIV/AIDS cases. Scientists believe it would take a two-part treatment to completely wipe out HIV. The human immunodeficiency viruses ( HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. ART also reduces the risk of HIV transmission. Estimated HIV infections among people who inject drugs in the US. Without treatment, it can lead to AIDS (acquired immunodeficiency syndrome). Without treatment, HIV can gradually destroy the immune system and advance to AIDS. It protects the virus from being destroyed by the immune system Human immunodeficiency virus (HIV) is the virus that causes HIV infection, which can develop into acquired immune deficiency syndrome (AIDS). government did The seven stages of the HIV life cycle are: 1) binding, 2) fusion, 3) reverse transcription, 4) integration, 5) replication, 6) assembly, and 7) budding. HIV medicines help people with HIV live Apr 12, 2024 · HIV treatment (antiretroviral therapy or ART) involves taking medicine prescribed by a health care provider. [2] [3] Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. View a timeline of the current Ending the HIV Epidemic initiative. Mar 26, 2019 · Still, a cure would facilitate the global eradication of HIV/AIDS. Visit vaccines. Infection with this virus results in the progressive depletion of the immune system, leading to Symptomatic HIV infection. Over time, they cause acquired immunodeficiency syndrome (AIDS), [1] [2] a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. The symptoms are the body's natural response to the virus. When used in combination with other AIDS drugs, these medicines Jun 7, 2022 · HIV treatment involves taking highly effective medicines called antiretroviral therapy (ART) that work to control the virus. Because they can’t get an HIV infection, mosquitoes can’t transmit HIV to humans. The right treatment can help prevent illness and keep HIV from progressing. HIV is a virus that attacks the immune system and can lead to AIDS, a clinical diagnoses that indicates an advanced stage of HIV. qn zf ub yp qb ze ys xt pa md