Its use for this purpose is contraindicated for In 2012, the International Federation of Obstetrics and Gynecology (FIGO) produced a chart detailing recommended dosages of misopros-tol when used alone, for a variety of gynecologic and obstetric indica-tions. In light of new evidence1–1. 56±3. 3 Registration status of misoprostolIn Australia misoprostol is now registered for use in obstetrics through the use of a 25μg oral tablet of misoprostol for the induction of labour (at term), and gynaecology in. on the regimen of misoprostol, the duration of waiting period and the types of miscarriage. Vaginal administration has higher effective-ness and lower rates of adverse effects than other routes of administra-tion; however 2. 6%) received 50 mcg of vaginal misoprostol the night prior to the procedure and the remaining 256 (55. Compared to expectant management, the Jun 1, 2023 · The varied uses of misoprostol in obstetrics and gynecology are reviewed, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. 7 However, it was not until 2015 that the WHO included this drug on the list of Feb 19, 2024 · Misoprostol is indicated, although not FDA-approved, for short-term treatment of active duodenal or gastric ulcers caused by other factors. 23), a combination of Mifepristone-Misoprostol was used. We hypothesize that sequential use of misoprostol followed by cervical Foley catheter will be associated with longer labor and adverse obstetrical outcomes when compared with using misoprostol alone as we believe that patients who require placement of a cervical Foley catheter after misoprostol represent an at-risk population as their cervical Apr 28, 2020 · Background: It is well-known since long time the beneficial effects of misoprostol particularly as a cervical softening agent in obstetric practice. Surgical evacuation has been used to empty the uterus. Although only approved by the US Food and Drug Administration (FDA) in 1988 for the prevention of stomach ulcers, misoprostol has many off-label uses applicable to obstetrics and gynecology . 2 hours) are recommended for induction of labor at term in women. It is also commonly used for obstetric and gynecologic indications, including induction of labor, prevention and treatment of postpartum hemorrhage, management of incomplete and spontaneous abortion, and termination of pregnancy (). fr. Oct 27, 2023 · The aim of much of the clinical literature on misoprostol alone was to establish recommended dosing and administration routes; as a result, clinical data on the effectiveness of currently endorsed misoprostol-alone protocols are sparse. Jan 4, 2001 · The article by Goldberg et al. Aug 1, 2000 · There is an urgent need to evaluate all the available data and organize a large randomized trial to determine the safety of misoprostol use in obstetric and gynecology practice. 4°F), and tachycardia to 180 beats per minute. The role of prostaglandins E1 and E2, dinoprostone, and misoprostol in cervical ripening and the induction of labor: a mechanistic approach Sep 15, 2020 · Besides this indication, misoprostol is also used off-label in obstetrics and gynecology, especially for inducing medical abortion. ) The pharmacokinetics of rectal misoprostol is similar to that of vaginal misoprostol, although with a lower overall bioavailability and a significantly lower peak plasma level. 2009;2(3):159-68. Methods: Using a ‘snowball’ sampling technique, we surveyed 228 gynecologists and obstetricians in Brazil ( n =123), Jamaica ( n =52), and the United States Aug 27, 2018 · American Journal og obstetretics and gynecology 2000;183 (4); 998-1002. Jun 28, 2021 · Only 2. 1 Service de gynécologie-obstétrique et médecine fœtale, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France; UMR Inserm U 930, université François-Rabelais, 2, boulevard Tonnellé, 37044 Tours cedex 9, France. A number of randomized trials and systematic reviews have evaluated its use in obstetric and gynecologic conditions. It is used off-label for a variety of indications in the practice of Obstetrics and Gynecology. Misoprostol is a synthetic prostaglandin E(1) analogue that is used off-label for a variety of indications in the practice of obstetrics and Oct 1, 2009 · Evidence‐based information about the safest regimens for multiple pregnancy indications are provided in this review of misoprostol. However, it has been used widely in obstetrics and gynecology practice because of its Aug 1, 2000 · Unlabelled: Misoprostol is prostaglandin E1 analogous and marketed for prevention and treatment of peptic ulcer disease. 1016/j. The objectives of this study were to assess the effectiveness and safety of vaginal misoprostol for induction of labour in IUFD. The regulatory landscape in the United States has changed since 2022, following the overturn of Roe v. 1,2 • Jun 23, 2017 · In 2012, the International Federation of Obstetrics and Gynecology (FIGO) produced a chart detailing recommended dosages of misoprostol when used alone, for a variety of gynecologic and obstetric indications. A common evidence-based medical regimen for early pregnancy loss uses misoprostol, a prostaglandin E1 analog, with a dosage of 800 μg, self-administered vaginally. 1 The authors identified more than 200 stu Jul 21, 2023 · The use of misoprostol is recommended for the following situations: legal abortion, uterine evacuation due to embryonic or fetal death, cervical ripening before labor induction (uterine cervix maturation), labor induction and management of postpartum hemorrhage. 6 In 2012, FIGO published its guidelines indicating 800µg misoprostol for the treatment of PPH. [Clinical uses of misoprostol in obstetrics and gynecology] Zhonghua Fu Chan Ke Za Zhi. Misoprostol is widely available, inexpensive, and easy to administer. Jan 15, 2014 · Objective: To compare the efficacy of vaginal and oral misoprostol for the induction of labor in women with intra-uterine fetal death (IUFD). Misoprostol is also used for a variety of indications in the practice of gynecology and obstetrics, including medication abortion, medical FIGO's updated recommendations for misoprostol used alone in gynecology and obstetrics. Int J Gynaecol Obstet, (1):65-74 2002 MED: 11818096 The approved misoprostol route and dose for this indication is oral administration of 200 µg four times daily with food. A synthetic prostaglandin E1 analogue Misoprostol is marketed as the oral preparation that prevents tread gastroduodenal damage induced by NSAIDs nonsteroidal anti-inflammatory drugs. Summary Miscarriages occur in 10 to 20% of all pregnancies. in this issue of the Journal reviews the evidence supporting the use of misoprostol in women at various stages of pregnancy. 2,14 There are only 2 clinical trials on misoprostol-alone regimens that use the currently endorsed regimen Oct 24, 2014 · The Obstetrician & Gynaecologist is an obstetrics and gynaecology journal publishing high-quality, peer-reviewed articles for continuing professional development in women's health. Mar 10, 2020 · Women’s Health. The optimal dosing of prostaglandin to achieve the highest efficacy with the lowest proportion of complications remains to be established. For some indications it is now the optimal choice, whilst for others it provides an important alternative, especially in low‐resource e and to reduce gastrointestinal side effects. This is called ‘off-label’ use. 12788/obgm. In 1980, under the guidance of Georges Misoprostol is a synthetic prostaglandin E1 analogue. Misoprostol is an essential drug for the management of postpartum hemorrhage. Methods: All the 200 patients were classified into two groups viz. Vaginal misoprostol is more effective with fewer side effects than other routes of administration ABSTRACT: Medication abortion, also referred to as medical abortion, is a safe and effective method of providing abortion. This article will review the notable history and provide an update as to the current and potential future clinical uses of mifepristone in obstetrics and gynecology. May 17, 2024 · One, misoprostol can be used in any trimester starting from diagnosis of the pregnancy all the way to the delivery of the baby as well as even after if there was postpartum hemorrhage or anything like that. In the study group - 88 pregnant aged 21-35 (28. omposite pack with mifepristone for the purpose of abortion up to 63 days gestation Aug 1, 2000 · Search life-sciences literature (Over 39 million articles, preprints and more) Jan 23, 2015 · Misoprostol, also known as Cytotec, is a synthetic analogue of prostaglandin E1. Nonetheless, in view of the side effects of misoprostol, its use as a first-line treatment is not indicated, and it should be reserved for difficult cases. DOI: 10. 0211in obstetrics and gynecology. 2012. In light of new evidence1–13 and through expert deliberation, this chart has now been revised and expanded (Fig. [10] [11] It is taken by mouth when used to prevent gastric ulcers in people taking nonsteroidal anti-inflammatory drugs (NSAID). First, do no harm should be the priority high in our thoughts when using these powerful agents. Some areas were Misoprostol is prostaglandin E 1 analogous and marketed for prevention and treatment of peptic ulcer disease. Give 2 doses and leave to work for 1-2 weeks (unless heavy bleeding or infection) Incomplete abortion. The purpose of our study was to compare the combination of Mifepristone and Misoprostol with the combination of a Foley balloon and Misoprostol for labour induction. The U. There are other, safer ways of inducing labor using balloon catheters. 1097/AOG. Materials and methods: In a randomised double-blind placebo-controlled trial, 50 women undergoing abdominal myomectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of pre-operative of rectal 400 μg misoprostol (n = 25) or placebo (n = 25) 1 h before the operation. The overenthusiastic use of misoprostol is equally dangerous and the guidelines as to its proper use do not guarantee safety. Misoprostol is a synthetic prostaglandin E(1) analogue that is used off-label for a variety of indications in the practice of obstetrics and gynecology, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. Methods: This retrospective study was carried out at two hospitals in which the medical records of patients who underwent hysteroscopic myomectomy between November 2017 and April 2022 were evaluated, and subjects were grouped depending on the May 20, 2015 · Benefit and risk of misoprostol in obstetric and gynecology field are explained. Email: jessica@figo. Its effects are dose dependent and include cervical softening and dilation, uterine contractions, nausea, vomiting, diarrhea, fever, and chills. There are no FDA-approved indications for the use of misoprostol as a single agent in obstetrics and gynecology. Apr 21, 2020 · The primary aim of the current study was to investigate the major complications of using misoprostol (such as hemorrhage, uterine laceration, and hysterectomy) in women with a history of 2 or more cesarean sections and in the second place, to evaluate the success rate of misoprostol use in pregnancy termination. The primary outcome was intra-operative Aug 28, 2023 · Pharmacological agents such as prostaglandins (dinoprostone and misoprostol) are commonly used to reduce the duration of labor and promote vaginal delivery. There is need to disseminate information about misoprostol especially in settings where women are likely to give birth outside of a health facility or Sep 4, 2009 · Misoprostol (15-deoxy-16-hydroxy-16-methyl PGE1) is a stable, synthetic form of prostaglandin E1 analogue. Despite its global use in gynecology and obstetrics, none of these applications are FDA-approved. 2 Service de gynécologie Oct 25, 2007 · BJOG: An International Journal of Obstetrics & Gynaecology; Ultrasound in Obstetrics & Gynecology; Prenatal Diagnosis; International Journal of Gynecology & Obstetrics; Acta Obstetricia et Gynecologica Scandinavica; Australian and New Zealand Journal of Obstetrics and Gynaecology; Journal of Obstetrics and Gynaecology Research; The Obstetrician FIGO's updated recommendations for misoprostol used alone in gynecology and obstetrics jessica morris 2017, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Misoprostol is currently the reference drug for pharmacological treatment in cases of induced abortion, both in the first trimester of pregnancy and at more advanced gestational ages. Food and Drug Administration (FDA)-approved medication abortion regimen includes mifepristone and misoprostol. ( 7 7 Tang OS, Gemzell-Danielsson K, Ho PC. Medical abortion with a pregnancy less than 9 weeks old: After taking 200 mg of Mifepristone for 24-48 hours, continue using 800 mcg of Misoprostol vaginally, lozenge cheek or sublingual. Misoprostol is an effective medication for cervical ripening and labor induction. Jul 13, 2023 · Median duration of misoprostol intravaginal placement (maximum 24 hours) and time to vaginal delivery (maximum allowable insertion time of 24 hours) for each dose were compared in previous multicenter open-label dose escalation trial published in the American Journal of Obstetrics & Gynecology. The most effective regimen for abortion includes pretreatment with oral mifepristone and following doses of misoprostol. Most Affiliations. 0000000000005464 Journal information International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 10 · Issue 7 Page 2555 Figure 2: How respondents actually used misoprostol. Jan 1, 2009 · Abstract. ration of Gynecology and Obstetrics, London, UK. S. Data collection and analysis. It avoids surgery and its associated complications. Preparing publication No abstract available. This is called ‘off-label’ use. Jul 1, 2020 · Randomised control studies of women undergoing open myomectomy for symptomatic fibroids who were given either misoprostol or placebo preoperatively. WHO recognizes the crucial role of misoprostol in reproductive health and Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. nd misoprostol for medication abortion in the first tri-mester. Misoprostol is widely used off-label in obstetric and gynecologic care and is included in the FDA-approved labeling of mifepristone for medication abortion. This article briefly reviews the varied uses of misoprostol in obstetrics and gynecology. 4 Department of Obstetrics and Gynecology, University of Campinas, São Paulo, Brazil. Medical Abortion With Cytotec The FDA hasn't approved Cytotec for use in obstetrics, but since 2002, doctors can prescribe this drug off-label if they consider to be the most preferable way of ending a pregnancy in Oct 28, 2019 · In 2006, the International Federation of Gynecology and Obstetrics (FIGO) recommended the use of misoprostol to treat PPH, especially in locations with scarce resources. 3 Use of misoprostol in obstetrics for medical abortion. 3% of the entire study population admitted to personal use of misoprostol. Oct 25, 2007 · Misoprostol use in obstetrics and gynecology in Brazil, Jamaica, and the United States. [Article in Chinese] Feb 19, 2024 · According to The International Federation of Gynecology and Obstetrics (FIGO) guidelines, misoprostol alone can be used for up to 13 weeks (off-label use) for termination of pregnancy. The FDA has approved the combination of mifepristone. In 2012, the International Federation of Obstetrics and Gynecology (FIGO) produced a chart detailing recommended dosages of misopros-tol when used alone, for a variety of gynecologic and obstetric indica-tions. . However, key safety considerations with its use include an increased risk of uterine rupture, tachysystole and hyperstimulation of pregnant women, which could potentially lead to a non-reassuring fetal heart rate and to fetal hypoxemia. Aug 9, 2012 · The WHO, the International Federation of Gynecology and Obstetrics (FIGO), the International Confederation of Midwives (ICM), and the Royal College of Obstetricians and Gynaecologists (RCOG) all support the use of misoprostol for PPH prevention and recommend that where oxytocin is not available or where birth attendants’ skills are limited Use of misoprostol in obstetrics and gynaecology. Jan 1, 2002 · The use of misoprostol for abortion induction is well known among the providers we interviewed in all three countries. The varied uses of misoprostol in obstetrics and gynecology are reviewed, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. 001]. 1 Its use for that indication however, has become limited and it is now used much more widely for postpartum haemorrhage. The study included 175 pregnant women, with gestational age 37-42 weeks. [11] Apr 8, 2024 · More information: Emily H. Missed abortion. Jan 22, 2002 · Objectives: To investigate current clinical use of misoprostol for the treatment of a range of reproductive health indications by providers in Brazil, Jamaica, and the United States. 3 Department of Women's and Children's Health, University of Liverpool, Liverpool, UK. The main focus of this article is to evaluate the potential use of misoprostol in Obstetrics and Gynaecology. Keywords: Gynecology; Gynécologie; Misoprostol; Obstetrics; Obstétrique; Off-label prescribing; Prescription hors AMM. Feb 19, 2013 · dose vaginal misoprostol (every 6 hours) or oral misoprostol (every. Table 1: Socio-demographic Misoprostol is licensed to treat gastric ulcers but now it is widely used for a variety of indications in osbtetrics and gynecology. Misoprostol, although originally introduced as a therapy for gastric ulcers, is now widely used in reproductive health. Jun 23, 2017 · In 2012, the International Federation of Obstetrics and Gynecology (FIGO) produced a chart detailing recommended dosages of misoprostol when used alone, for a variety of gynecologic and obstetric indications. The revised Cochrane risk-of-bias tool for randomised trials was used to assess the risk of bias. However, it has been used widely in obstetrics and gynecology practice because of its effectiveness, low cost, stability in light and hot climate conditions, and ease of administration compared with its licensed counterparts—dinoprostone and gemeprost. Nov 2, 2018 · The most common challenges to updating and implementing guidelines were: lack of supportive policy or programs for use of misoprostol; misoprostol not widely and regularly available; misoprostol not included on national EML; healthcare providers not knowing about the guidelines; lack of national guidelines/misoprostol not included in national WHO recognizes the crucial role of misoprostol in reproductive health and has incorporated recommendations for its use into 4 reproductive health guidelines focused on induction of labor, prevention and treatment of postpartum hemorrhage, and management of spontaneous and induced abortion. May 1, 2013 · DOI: 10. 4. Van der Veen N, Brouns J, Doornbos J and Van Wijngaarden W. Complications are rare Apr 1, 2015 · The use of misoprostol to promote cervical dilatation before diagnostic hysteroscopy or surgical procedures is beneficial for premenopausal women but not for postmenopausal women. for abortion throughout pregnancy. Twenty-seven percent of the providers interviewed use misoprostol alone for first trimester abortion. 1 Recent food intake and antacid use reduces the absorption of orally administered misoprostol. Keywords: misoprostol, prostaglandin, haemorrhage, gynaecology. So, it's important to kind of get an understanding of Aug 21, 2023 · Medical guidance in the US and around the globe supports use of misoprostol . Medication abortion involves the use of medicines rather than uterine aspiration to induce an abortion. Rev Obstet Gynecol. International journal of gynaecology and obstetrics: the official organ of the International Oral misoprostol should be used only up to 7 weeks of gestation. Misoprostol has been shown to have two primary effects when used in labor induction: to increase uterine contractility and to soften the cervix, primarily through its ability to degrade collagen Jan 1, 2000 · Misoprostol (Cytotec, Searle) is a prostaglandin E1 analogue marketed as an antigastric ulcer agent. Adhikari et al, Vaginal Compared With Oral Misoprostol Induction at Term, Obstetrics & Gynecology (2023). Some areas were Dec 2, 2020 · Of these, 462 had office hysteroscopy alone; 206 (44. Apr 29, 2017 · Misoprostol, a prostaglandin E1 analogue, is approved by the Food and Drug Administration (FDA) for gastric ulcer prevention with long-term anti-inflammatory medication use. Recommendations of FIGO are 800 mcg of misoprostol given sublingually administered every 3 hours. 14–17 It is also more acceptable to women than MVA. Ideally used 48h after mifepristone 200mg. So, it has many uses via many routes, many doses throughout your entire pregnancy. – 7]. gle agentdoi: 10. The correct dosage varies greatly according to gestation, indication and route of administration - using the correct dosage is vital for success and to prevent complications. The use of double doses of oral 600 mcg misoprostol. Methods and results Aug 9, 2012 · The WHO, the International Federation of Gynecology and Obstetrics (FIGO), the International Confederation of Midwives (ICM), and the Royal College of Obstetricians and Gynaecologists (RCOG) all support the use of misoprostol for PPH prevention and recommend that where oxytocin is not available or where birth attendants’ skills are limited Background: Early pregnancy loss is a common event in the first trimester, occurring in 15%-20% of confirmed pregnancies. Jun 5, 2017 · The uterotonic effects of misoprostol and its impact on cervical softening have made misoprostol a widely used therapy in obstetrics and gynecology . Some areas were 1 International Federation of Gynecology and Obstetrics, London, UK. This is called ‘off-label' use. Consequently, mifepristone has become one of the most restricted pharmaceuticals worldwide, severely limiting the exploration for other uses. It Uses of misoprostol in obstetrics and gynecology. In contrast to misoprostol, PGE2 (dinoprostone) is approved by the FDA as a vaginal insert containing 10 mg of dinoprostone for the initia-tion and/or continuation of Misoprostol is an analogue of prostaglandin E1 (PG E1) which was registered in many countries during the second half of the 1980s under the proprietary name Cytotec (Pharmacia), for the treatment of peptic ulcers, particularly those caused by non-steroidal anti-inflammatory drugs [5. 2011;283(1):1-5. FIGO's updated recommendations for misoprostol used alone in gynecology and obstetrics. who have not had a previous cesarean delivery ( Table 1). So, due to its wide ranging applications in reproductive health, misoprostol is on the model list of essential medicines of World Health Organization. • Misoprostol only is a regimen for medication abortion that is commonly used worldwide. Study Design: A prospective randomized clinical trial Feb 19, 2021 · The BEGIN trial (buccal vs vaginal misoprostol combined with Foley catheter for cervical ripening at term) was an institutional review board–approved, randomized clinical trial conducted from June 2019 to January 2020 comparing identical doses (25 μg) of buccal misoprostol and vaginal misoprostol along with a Foley catheter for induction of labor. 009 Corpus ID: 20692073; WHO recommendations for misoprostol use for obstetric and gynecologic indications @article{Tang2013WHORF, title={WHO recommendations for misoprostol use for obstetric and gynecologic indications}, author={Jennifer H. Misoprostol is cheap, stable at room temperature and easily to access it. 1). Electronic address: emmanuel. Jan 31, 2017 · Practically prostaglandin analogues are routinely used for induction of labour in cases of IUFD. 55. 4%) patients had no cervical ripening. Over the last 15 years, multiple applications of this agent in obstetrics and gynecology have Aim: In this study, we aimed to evaluate the effect of using two doses of rectal misoprostol on postoperative results in hysteroscopic myomectomy. study group (Group I) with 100 patients and Jul 13, 2009 · A single dose of 600 mcg oral misoprostol has been shown to be as effective as manual vacuum aspiration (MVA) in the management of incomplete miscarriage with complete evacuation rates of 95–99% after 1–2 weeks of follow-up. However, it has been used widely in obstetrics and gynecology practice Mar 1, 2013 · The hyperthermic effects of misoprostol are not only unpleasant, but they may also be life threatening: in one reported case, a woman who received 800 μg of oral misoprostol for postpartum hemorrhage prophylaxis subsequently developed chills, rigors, hyperpyrexia to 41. UNLABELLED Misoprostol is prostaglandin E1 analogous and marketed for prevention and treatment of peptic ulcer disease. ijgo. Misoprostol is a synthetic prostaglandin E (1) analogue that is used off-label for a variety of indications in the practice of obstetrics and gynecology, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. 5(0–10); p=. Jan 24, 2015 · Moreover, misoprostol has been used in obstetrics and gynecology, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. Misoprostol is inexpensive, stable at room temperature, and available in more than 80 countries, making it particularly useful in resource-poor settings. Differences in the mechanism of action between misoprostol and PGE2 may contribute to their variable effects in the cervix and myometrium, and should be considered to optimize outcomes. Keywords: Cervical ripening; Hysteroscopy; Induced abortion; Induction of labor; Misoprostol; Postpartum hemorrhage. An alternative is misoprostol only which should only be used when mifepristone is not available. It has anti-secretory and mucosal protective properties and was originally developed in the 1970s for the prevention of nonsteroidal anti-inflammatory drugs (NSAIDS)-induced peptic ulcers. 2 Gynuity Health Projects, New York, NY, USA. Available in tablet form, it can be administred vaginally, rectally, sublingually and bucally. 5. only. Key content A combination of mifepristone and misoprostol is the gold standard treatment for induction of labour in women with late intrauterine fetal death. Jul 13, 2011 · He is a Senior Professor and Consultant in obstetrics and gynecology with over 30 years of experience. 12. May 20, 2015 · Misoprostol is licensed to treat gastric ulcers but now it is widely used for a variety of indications in osbtetrics and gynecology. In light of new evidence 1-13 and through expert deliberation, this chart has now been revised and expanded (Fig. June 2017. pital setting. The reported pain score following hysteroscopy was significantly lower among patients who received misoprostol [4(0–10) vs. Available in tablet form, it can be administred vaginally Jul 21, 2022 · Description of the intervention. Recently, medical treatment using misoprostol has been studied for the management of miscarriage. The overenthusiastic use of oxytocin is dangerous. org BACKGROUNDIn 2012, the International Federation of Obstetrics and Gynecology (FIGO) produced a chart detailing recommended dos-age. Clark S, Blum J, Blanchard K, Galvao L, Fletcher H, Winikoff B. Methods: In this prospective study, consecutive series of 100 women with IUFD ≥ 28 weeks of gestation are studied. simon@univ-tours. (1st Trimester) 800mcg vaginally or sublingual 3-hrly (max x3 within 12 hrs)a. Slightly fewer use misoprostol for second trimester abortion in combination with D&E (23%) or as a labor induction agent (13%). 1998 Jan;33(1):55-7. Misoprostol is a synthetic prostaglandin E 1 analog developed for the prevention and treatment of peptic ulcers (). Misoprostol and termination of pregnancy: is there a need for ultrasound screening in a general population to assess the risk for adverse outcome in cases of uterine anomaly. (1st Trimester) 800mcg vaginally 3-hrly (max x2) or sublingual 600mcg 3-hourly (max x2)b. Keep in view, study aimed to evaluate the efficacy of vaginal misoprostol 400 mcg before endometrial biopsy in premenopausal women. Professor Rushwan has a wide range of international expertise and has been actively involved in the field of women's health for the past 2 decades, including clinical work, health services management, research, and teaching. 9°C (107. Oct 24, 2014 · The Obstetrician & Gynaecologist is an obstetrics and gynaecology journal publishing high-quality, peer-reviewed articles for continuing professional development in women's health. Misoprostol is licensed to treat gastric ulcers but now it is widely used for a variety of indications in osbtetrics and gynecology. Tang and Nathalie Kapp and Monica Dragoman and Joao Paulo de Souza}, journal={International Journal of Gynecology 1. Arch Gynecol Obstet. Conclusions: Knowledge about the safe, life-saving and effective use of misoprostol among Nigerian women is low. of misoprostol when used alone, for a variety of gynecologic and obstetric indications. dn qm tq ga sa jm bp vn mb dl