Xylene toxicity. ru/5t5qnu/what-is-a-high-pulse-rate-during-pregnancy.
Chronic low-level occupational or industrial exposure to toluene can cause toxicity. Not for medicinal, household or other use. Toxic by all routes of exposure (ie, dermal, ingestion, and inhalation), 4-xylene can cause effects including headache, dizziness, skin and eye irritation, kidney and liver damage, pulmonary edema, coma, and death. On exposure the vapours are rapidly absorbed through the lungs and the slowly through the skin. Feb 27, 2012 · Considering the toxicity of xylene and its hazards, various substitutes, including vegetable oils and mineral oils, have been tried in the past. Introduction Dimethylbenzene, or technical xylene, is an organic solvent containing three major isomers: meta-xylene, para-xylene, and ortho-xylene (m-, p-, and o-xylene). The heat of a fire may cause containers to explode and/or cause thermal degradation of 2-xylene, producing acrid smoke and toxic gases. FIRST AID Eye Contact Xylenes are a natural products of many plants, and are a component of petroleum and coal tar. The primary problem with using xylene is its toxicity; long-term exposure is particularly injurious to health. Skin Contact: SKIN IRRITANT. Breathing xylene vapors in small amounts can serious exposure, xylene can cause sleepiness, vapors are mildly irritating to the skin, eyes, burning pain. 24-Hour Emergency contact. The p- stands for para-, indicating that the two methyl groups in p -xylene occupy the diametrically opposite substituent positions 1 and 4. 1981. Jul 15, 2017 · The results of the current study showed that xylene is toxic to human lymphocytes at 1,000 and 2,000 ng/L after 6 hr of exposure. Symptoms include pain, redness, and swelling. The most common route of exposure is via inhalation. , 2016; Garg and Gupta, 2019; Sjöström et al. Although this compound is insoluble in water, it pollutes the marine environment. It is found in glues, adhesives, printing inks Oct 2, 2011 · In this study, we introduced a novel, non-toxic xylene substitute (SBO), which was generated through a mixture of 86% of white oil No. Health and safety authorities in most countries, including Australia, recommend a threshold limit value (TLV) of 100 ppm in the working environment. It should also be noted that any future epidemiological observations of cancer risks associated with toluene or xylene would have to take account of the suspected Mar 7, 2024 · FIGURE 1. The r … Mar 3, 2010 · The toxicity of xylene to human health and the environment warrants its careful control or, ideally, its elimination from the laboratory. Three cases of xylene poisoning occurred after prolonged inhalation of paint fumes. Gastric lavage, hemodialysis and hemoperfusion are some of the techniques used for speedy removal of large doses of xylene. When exposed to sunshine, xylene readily evaporates and splits into various Sep 1, 1980 · Xylene as used in biomedical laboratories has been toxic in workers to the point of causing permanent disability. Research into these risks is under-studied even as BTEX levels in the atmosphere are predicted to rise. Liver: Changes in liver weight. , 2022). This review focused on the ecotoxicological hazards of m-, o-, and p-xylene, as well as mixed xylene, on aquatic organisms. Xylene, also known as Dimethyl Benzene, is a colourless, sweet smelling liquid or gas that is widely used as a solvent. Also known as Dimethyl Benzene, Xylene is a colourless, sweet smelling liquid or gas that is widely used as a solvent. Xylene cyanol FF Revision Date 28-Dec-2021 Acute Toxicity Product Information No acute toxicity information is available for this product Component Information Toxicologically Synergistic Products No information available Delayed and immediate effects as well as chronic effects from short and long-term exposure Background: Xylene is one of the most commonly used solvents in industrial and medical technologies. One patient was dead on admission, while the other two recovered after at least 15 hours' loss of consciousness. Toluene and xylene poisoning can occur when someone swallows these substances, breathes in their fumes, or when these substances touch the skin. It can cause systemic toxicity by ingestion or inhalation. Demyelination and gliosis are histologically demonstrable in Aug 8, 1970 · Three cases of xylene poisoning occurred after prolonged inhalation of paint fumes. Influence of Xylene on Toxicity of Toluene after Simultaneous Exposure . Studies on humans and animals have shown that xylene is well-absorbed by inhalation and oral routes. 22 Animal studies, then, have limited value in directly evaluating risk to humans exposed to xylene, but they enable us to recognise and investigate the extensive biochemical and pathological effects of Toluene and xylene are strong compounds that are used in many household and industrial products. Coconut oil was selected, as it is, profusely available in the tropical world Xylene vapor may also off-gas from the toxic vomitus of victims who have ingested xylene. 9-1. Symptoms/effects after skin contact : Irritation. 2 and 14% of N-heptane. 1970 Combined environmental exposures to the volatile organic compounds (VOCs) Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) pose clear risks to public health. Fires involving 2-xylene may be extinguished with dry chemical, CO2, water spray, fog, or foam. A smaller percentage is converted into the epoxide. Five cases of varying severity observed in California cytotechnologists are discussed for the purpose of calling attention to the harmful effects of xylene. May 4, 2022 · Technical xylene is a compound of massive production that is used in applications such as petrochemical and healthcare laboratories. These techniques can help in reversal of acute systemic toxicity due to xylene exposure. , 2020b; Yu et al. May 4, 2022 · Only one scholarly research article was identified regarding the female reproductive toxicity of technical xylene and its isomeric compounds of m-xylene, p-xylene, and o-xylene. The patient sustained an extensive degloving injury to his lower extremity. PUBLIC HEALTH STATEMENT FOR TOLUENE. Prolonged exposure to xylene leads to significant amount of solvent Apr 11, 2022 · Practice Essentials. (1970) exposed rats, guinea pigs, monkeys, and dogs to o-xylene at either 780 ppm (3358 mg/m 3) for 8 h/d, 5 d/wk for 30 exposures or 78 ppm (389 mg/m 3) continuously for 90 d. Jul 6, 2009 · Xylene is an aromatic hydrocarbon widely used in industry and medical technology as a solvent. Jul 6, 2024 · Product name: Xylene; CBnumber: CB0130912; CAS: 1330-20-7; EINECS Number: 215-535-7; Synonyms: Xylene,Xylenes; Relevant identified uses of the substance or mixture and uses advised against. 1 mg/m 3 for xylene, which is an estimate of the air level for the general population (including sensitive subgroups) that is likely to be without risk for deleterious effects over lifetime Jun 1, 2024 · One of the notorious groups of toxic VOCs – known as “BTEX” – is made up of four members: Benzene, Toluene, Ethyl-Benzene, and different isomers of Xylene as shown in Fig. 21 exacerbation of xylene-induced enzymatic changes21 and altered toxicity of other solvents. Jan 11, 2024 · Toluene is a simple benzene derivative also known as methylbenzene, phenylmethane, or toluol. As a volatile solvent, misuse or abuse is common, resulting in an acute toxidrome. The mechanism of action of xylenes was also demonstrated in details. The individual isomers of xylene are: ortho-, meta-, and para-xylene. All prepared formulations Xylene. Xylene is very soluble in Nov 23, 2015 · In addition long term exposure to xylene may cause hazardous effects on respiratory system, central nervous system, cardiovascular system, and renal system. Toxicol Appl Pharmacol 60:535-548. Company: Chemicalbook m-Xylene CAS#: 108-38-3 o-Xylene CAS#: 95-47-6 p-Xylene CAS#: 106-42-3 Reasons for Citation contact can cause a skin rash, dryness and redness. Oxidative stress may also play a role in xylene toxicity. Exposure to xylene occurs in the workplace and when you use paint, gasoline, paint thinners and other products that contain it. Highlights. The toxic effects of xylene on the body weight, blood parameters, and percentage of hematopoietic stem and progenitor cells in mice. In addition, it finds application as a solvent in many sectors, paints, polishes, dyes, and medical technologies. 6 mg/cm 2 per hour (Dutkiewicz and Tyras, 1968). Summary of Available Data on the Influence of Ethylbenzene on Metabolism of Xylene and The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. While no direct human evidence is available, there is recent evidence of carcinogenicity of toluene and xylene at high concentrations in experimental animals. A shorter version, the ToxFAQsTM, is also available. Xylenes are on the Right to Know Hazardous Substance List because they are cited by OSHA, ACGIH, DOT, NIOSH, DEP, IARC, NFPA and EPA. Capsicum and garlic were extracted in xylene. Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc. Higher concentrations or longer exposure periods can cause eye The term total xylenes refers to all three isomers of xylene (m-, o-, and p-xylene). Jan 1, 1994 · These include altered metabolism of xylene, 12. When inhaled, toluene is rapidly absorbed into the bloodstream and distributed to lipid-rich tissues (including the brain) where it accumulates. Xylene, an aromatic hydrocarbon is widely used in industry and medical laboratory as a solvent. Xylene is an aromatic hydrocarbon widely used in industry and medical technology as a solvent. When applied to the skin, musk xylene can induce a weak sensitizing effect (Parker 1986). Can be absorbed through the skin, but harmful effects are not expected. , 1960). These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. Like toluene, which was the subject of the previous Toxic Tuesday, xylene is an aromatic Further studies on xylene poisoning are indicated since xylene is reported to induce a degree of narcosis at levels below those considered acceptable. Recently, the amount of the major metabolite of xylene, … May 4, 2022 · Only one scholarly research article was identified regarding the female reproductive toxicity of technical xylene and its isomeric compounds of m-xylene, p-xylene, and o-xylene. 1. Additional information relevant to the female reproductive toxicity of xylene comes from 12 Identification. People who breathe high levels may have dizziness, confusion, and a change in their sense of balance. Uses advised against: none; Company Identification. Xylene is primarily a synthetic chemical. This Public Health Statement summarizes the Agency for Toxic Substances and Disease Registry’s (ATSDR) findings on toluene, including chemical characteristics, exposure risks, possible health effects from exposure, and ways to limit exposure. Symptoms of xylene poisoning include CNS effects (headache, dizziness, Xylene Public Health Statement. . Maternal toxicities were reported as reduced body Early reports on the toxicity of xylene in humans are often difficult to assess because of impurities (including benzene) present in commercial xylene. 1982; Morley et al. Two painters who survived exposure to an estimated 10,000 ppm of xylene and several workers who were exposed to an estimated 700 ppm of xylene had transiently elevated serum transaminase levels (Klaucke et al. 7-305 mg/l. identification xylene cas - no: 1330-20-7 specific target organ toxicity (repeated exposure): inhalation [ears] - category 2 aspiration hazard - category 1 Oct 14, 2020 · Xylene is one of the few chemicals that don’t mix with water. From this trail it is concluded that p-and o-xylene isomers seemed to be more toxic than m-xylene to progeny (Hood and Ottley, 1985). Toluene is an aromatic hydrocarbon with narcotic and neurotoxic effects and, like all inhalants, has the potential to induce addiction xylene 1. Liquid xylene splashed in ethe exposure, the more severe the symptoms. Analysis showed that xylene comprised more than 90% of the solvent in the paint, the total solvent comprising 34% of the paint by weight. As every other profession became cautious of the occupational hazards, the A case of unique acute bone marrow toxicity and pancytopenia following subcutaneous exposure to lead chromate, xylene, and ethylbenzene in a previously healthy patient is reported. Workers in certain forces appear to have the greatest potential for exposure to high concentrations of xylene - histopathology technicians and painters are two such groups. Formula A "capsicum xylene extract + emulsifier", Formula B "garlic xylene extract + emulsifier", Formula C "capsicum xylene extract in boiled linseed oil + emulsifier" and Formula D "garlic xylene extract in boiled linseed oil + emulsifier ". 1. This article is for information only. Xylene (C 8 H 10) is a colorless, flammable liquid with a pleasant aroma. The experiments were set up using an individual pollutant in a 25-mL bottle sealed with a rubber stopper and aluminum cap since BTEX are volatile. : 18 March 2015 : Xylene : Aromatic hydrocarbon : Dimethylbenzene, Methyl Toluene, Xylol, Xylenes (IBC code LEL: . [13 14] Xylene has produced fetotoxic effects like delayed ossification and behavioral effects in animals, in the absence of maternal toxicity. Each peer-reviewed Tox Profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicological and epidemiological information on a substance. Ambient air concentrations in the United States have been reported to average 0. Unfortunately, it’s extremely toxic for the environment and human health. : PCS 08006. Currently available studies regarding xylene's adverse effects with credible designs were dated almost twenty years ago. [1][2] These characteristics make glycol ethers essential in May 10, 2024 · Symptoms may include headache, nausea, dizziness, drowsiness, and confusion. Xylene is a common component of solvents used in the printing, painting, rubber, leather and agricultural industries. Death has been reported after exposure to toluene at 1, 800–2,000 ppm for 1 hour. Toluene (methylbenzene, toluol, phenylmethane) is an aromatic hydrocarbon (C 7 H 8) commonly used as an industrial solvent for the manufacturing of paints, chemicals, pharmaceuticals, and rubber. Environmental Protection Agency (EPA) identifies the J Environ Qual 20:420-424. From 1987 to 1993, according to EPA's Toxic Chemical Release Inventory, xylene releases to land and water totalled nearly 4. Oct 15, 2022 · As the GABAa receptor is a possible target for xylene-induced nervous system toxicity, and as this receptor may behave differently during brain development, exposure to xylene during the period of brain growth could be critical (de Groot 2017). It occurs naturally in petroleum and coal tar. Xylene can also be absorbed into the body following inhalation, ingestion or skin contact. The rate at which xylene is absorbed through human skin that is immersed in liquid xylene has been estimated to be 4. The ATSDR Interaction Profile succintly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. It also occurs naturally in petroleum, coal and wood tar. I would say that there IS a difference in the toxicity. The toxicity of xylene is a concern, especially when it comes to exposure through inhalation or skin contact. It is widely used for the production of ethyl benzene, polyester, and plastic, and also acts as a solvent in paints or varnishes. It is important to improve health policies, launch xylene related health and toxicity awareness campaigns, to get rid Toxicological Profiles. Basis for original (SCP) IDLH: The chosen IDLH is based on the following statements by ANSI [1971]. Several health hazards of xylene have been documented in literature. The health concerns of xylene are well documented in animals and human. It is one of the three isomers of dimethylbenzene known collectively as xylenes. Toxicological Profiles (Tox Profiles) are a unique compilation of toxicological information on a given hazardous substance. The available animal information is insufficient to connect xylene with any reproductive effects. It is identified as CAS#108-88-3, and the United Nations Department of Transportation's number for toluene is UN#1294. Mortality was 3 of 15 rats, none of 15 guinea pigs, none of 2 dogs, and 1 of 4 monkeys. Relevant identified uses: For R&D use only. The EPA reference concentration (RfC) is 5 mg/m 3 for toluene and 0. SECTION 12: Ecological information 12. C C Xylene is irritating to the skin, eyes, and respiratory tract. Each peer-reviewed profile identifies and reviews the key literature that describes toxicologic 6 days ago · The xylene isomers appear to have low to moderate toxicity to fish. Toluene and xylene. Xylene Uses and Industrial Applications Little information is available about the toxicity of toluene, ethylbenzene and xylene acting on macrophytes, and their toxicity data are rarely used in regulation and criteria decisions. 2 mg/kg/day is based on a NOAEL of 250 mg/kg/day (duration-adjusted, 179 mg/kg/day) for the lack of any overt neurological toxicity or systemic toxicity in rats that received oral gavage doses of mixed xylene (plus 17% ethylbenzene) 5 days/week for 2 years ; an uncertainty factor of 100 was applied to the May 25, 2018 · The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. [11,16,19,20,21,22,23] However, most of them showed an inconsistent outcome, which motivated us to take up this study. If larger amounts of xylene are absorbed this can result in breathing problems, damage to the liver and kidneys, cause a loss of consciousness, heart failure and death. Xylene is an aromatic hydrocarbon known for its wide usage in tissue processing, staining and cover slipping in the histology laboratory. The single one-generation reproductive toxicity study of xylene in animals included evaluation of endpoints of female reproductive toxicity such as mating and fertility. Xylene occurs in three forms – m-xylene, o-xylene, and p-xylene – and together they are referred to as xylenes. For more information, call the ATSDR Information Center at 1-800-232-4636. , 2014; Masih et al. 5–9. Xylene or xylenes (used interchangeably) is a colorless, sweet-smelling chemical occurring naturally in petroleum, coal and wood tar. Toxicity Ecology - general : Toxic to aquatic life. Inhaling xylene vapor causes skin, eye, respiratory tract, and mucous membrane irritation. o -Xylene is a colourless slightly oily flammable Xylene, which has an additional methyl group at various positions, is also oxidized into benzoic acid derivatives. This can cause headaches, dizziness, vertigo and drowsiness. Xylene inhaled by a woman can reach a developing fetus and can contaminate her breast milk. In fact, the term "xylene" was often used as a general term for various solvents, including "pure" toluene and "pure" benzene as well as mixtures of various solvents. Chemical industries produce xylene from petroleum. Further studies of xylene toxicity at different stages of pregnancy are required to improve safety guidelines for technical xylene exposure. Glycol ethers possess a unique combination of physical properties, including high solvency, low evaporation rates, and miscibility with both water and organic substances. For massive fires in A chronic-duration oral MRL of 0. Abstract. 18 ppb (0. , of which about 81 percent was to land. Availability of Hazard Identification Document for Xylene. This information is important because this substance may harm you. These releases were primarily from petroleum industries which produce Xylene, a hazardous and noxious substance, has been major concerns with regard to heterogeneity and eco-toxicity towards aquatic organisms. However, research on the gene expression profiles associated with xylene-induced toxicity in HSPCs, and effective therapeutic interventions, remains scarce. 78 μg/m3) in remote rural areas and up to 99 ppb (430 μg/m3) near industrial facilities and roadways (NLM, 1998). Summary: There are three forms of xylene in which the methyl groups vary on the benzene ring: meta-xylene, ortho-xylene, and para-xylene (m-, o-, and p-xylene). Xylene is a colorless, sweet-smelling liquid that catches on fire easily. It is a constitutional isomer of m -xylene and p -xylene, the mixture being called xylene or xylenes. Andersson K, Fuxe K, Nilsen OG, et al. Specific target organ toxicity (single exposure) : Not classified Specific target organ toxicity (repeated exposure): Not classified Aspiration hazard : May be fatal if swallowed and enters airways. Nov 23, 2015 · Xylene exposure through the skin could lead to a prominent change in fetus enzymes; while trailing by ingestion route lead to maternal death, delay development, and cleft palate. The hazards of xylene are well documented, making it a potential occupational hazard for the histopathological technicians. There was no evidence of toxicity of xylene. Nov 1, 2017 · Xylene, a hazardous and noxious substance, has been major concerns with regard to heterogeneity and eco-toxicity towards aquatic organisms. Oct 19, 2020 · The main constituent in most modern solvents is toluene (C 7 H 8 ), also known as methylbenzene, a lipid-soluble aromatic hydrocarbon. Saillenfait et al. It is widely used as a solvent and thinner for paints and varnishes, often in combination with other organic compounds and as a solvent in glues o-Xylene ( ortho-xylene) is an aromatic hydrocarbon with the formula C 6 H 4 (CH 3) 2, with two methyl substituents bonded to adjacent carbon atoms of a benzene ring (the ortho configuration). Adequate controls for the proper use, handling and storage of Xylene containing materials reduce the risk of hazardous exposures and illness in the workplace. (A) The body weight of mice on the 5 th, 10 th, 15 th, 20 th, 25 th day of xylene exposure (left), Effects of xylene and CF+ xylene on RBC (middle) and WBC (right), WBC: white blood cell; RBC: red blood cell; The data were presented as the mean ± SD. , 2019; Kuppusamy et al. This review focuses on the available … The toxicity of xylene and safety measures to counteract the hazards are discussed and the pros and cons of using various substitutes that claim to be much safer, better and faster are enlists. Xylene is also known as xylol or dimethylbenzene. Also, vapor may travel a considerable distance to a source of ignition and flash back. Exposure to xylene can cause acute and chronic effects in humans and animals. It is a flammable liquid that requires utmost care during its usage. Although several xylene substitutes are now available, a Jan 24, 2024 · Xylene is a highly versatile chemical compound commonly used in various industries. p-Xylene ( para-xylene) is an aromatic hydrocarbon. Toluene and xylene are strong compounds that are used in many household and industrial products. These hydrocarbons have high vapor Apr 1, 2019 · The assessment of benzene, toluene, ethyl-benzene, and xylene (BTEX)-contaminated soil toxicity was performed using a sulfur-oxidizing bacteria (SOB) assay. Mixed xylene is a mixture of the three isomers and usually also contains 6–15% ethylbenzene. The variation between each individual isomer is generally small, although the para isomer is generally slightly more toxic than the meta and ortho isomers. Jan 1, 2024 · Xylene Toxicity. Jenkins et al. 0. Exposure Potential. LC50 values reported for marine and freshwater fish range from 1. The obtained extracts were used to prepare four emulsifable concentrates "EC's". Apr 30, 2022 · The action of the medicinal plant Tribulus terrestris (TT) on bovine ovarian cell functions, as well as the protective potential of TT against xylene (X) action, remain unknown. These different forms are referred to as isomers. Nov 9, 2021 · The release of xylene isomers from storage tanks poses a significant threat to petrochemical industries, and their safe transportation and storage is a widely researched topic. In the blood, it is primarily bound to serum proteins and accumulates in adipose tissue . The wound was contaminated with traffic pai … inhalation/rat. food (ATSDR, 2007). For massive fires in For more information, contact: Interaction Profile: Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX). The U. SBO had a high boiling point (188°C) and flash point (144°C) coupled with a scentless and decreased volatility. Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene. Nutritional and Gross Metabolic: Weight loss or decreased weight gain. Mar 8, 2024 · Xylene exposure is known to induce toxicity in hematopoietic stem and progenitor cells (HSPCs), leading to bone marrow suppression and potential leukemogenesis. lowest published toxic concentration: 300 ppm/6H. High serum levels of musk xylene in women may be associated with gynecological abnormalities, including mild insufficiency of the ovaries and Also, vapor may travel a considerable distance to a source of ignition and flash back. ) Chemicals Selected by OEHHA for Consideration for Listing by the Developmental and Reproductive Toxicant Identification Committee and Request for Relevant Information on the Reproductive Toxicity Hazards of Deltamethrin and Xylene. A recent study indicates that xylene is commonly found in the soil, water, and air. . Nov 29, 2018 · Following an acute exposure to xylene, it is advisable to shift the person to a well-ventilated room away from the source of exposure. This public health statement tells you about xylene and the effects of exposure to it. Maternal toxicities were reported as reduced body What is xylene? There are three forms of xylene in which the methyl groups vary on the benzene ring: meta-xylene, ortho-xylene, and para-xylene (m-, o-, and p-xylene). DO NOT use it to treat or manage an actual poison exposure. Xylene is typically detected in ambient air, and can also be found in groundwater and. Causes moderate to severe irritation. This review focused on the ecotoxicological hazards of m Mar 10, 2024 · Glycol ethers have been a versatile and essential solvent group widely utilized in industrial and commercial settings since their initial development in the 1930s. 8 billion lbs. Jun 13, 2017 · Xylene also is used as a solvent in the rubber, printing, and leather industries. 1 Uses Technical (industrial) xylene is a mixture of the 3 isomers plus ethylbenzene (6-15%) and occasionally toluene, trimethyl benzene and other trace components. A severe exposure can cause unconsciousness. At acute-duration inhalation concentrations as low as 50 ppm, xylenes produce irritant effects on the eyes, skin, and mucous membranes; impaired respiratory function; and mild central Xylene, or dimethyl benzene C6H4 (CH3)2 is an organic aromatic hydrocarbon. Fires involving 3-xylene may be extinguished with dry chemical, CO2, water spray, fog, or foam. Cyclic hydrocarbon xylene is a contaminant of the environment. It's a colorless, sweet-smelling liquid that's derived from petroleum. The aim of the present in vitro study was to elucidate the influence of TT, X and their combination on basic bovine ovarian cell functions. 37 2-9. No animal studies evaluated potential effects of xylene on the estrous cycle. 1 (Du et al. “Exposure at 1,000 ppm for 5 minutes or less will probably allow self-rescue with no irreversible injury. This paper focused on modeling the environmental, health, and safety effects of P-xylene and O-xylene leakage from storage tanks via Areal Locations of Hazardous Atmospheres (ALOHA) and Wireless Information System for When pure, xylene is a clear, colorless liquid crude petroleum and is used widely in many found in small amounts in gasoline. USES/CIRCUMSTANCES OF POISONING 4. 1% (10% LEL, 900-1,100 ppm) Original (SCP) IDLH: 1,000 ppm. Xylene is distributed rapidly into all tissues of the body, especially into the adrenals, bone marrow, brain, spleen, and adipose tissue (Fabre et al . To compare the effectiveness of SBO and xylene in histology, a wide range Two of these studies suggest that acute-duration exposure to high levels of xylene may result in hepatic toxicity. Both patients had transient liver cell damage, and one H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract Abstract. S. Despite its usefulness, xylene can be toxic and may have negative health effects. The results extended the knowledge on toxic effects of toluene, ethylbenzene and xylene on aquatic plants. studied the maternal inhalation exposure of technical xylene and its toxicity on rat development . This Public Health Statement is the summary chapter from the Toxicological Profile for Xylene. The heat of a fire may cause containers to explode and/or cause thermal degradation of 3-xylene, producing acrid smoke and toxic gases. The hazards of xylene are well documented, making it a potential Information on the toxicity of xylene in humans comes from case reports, occupational studies, and studies on volunteers. It is one in a series of Public Health Statements about hazardous substances and their health effects. SEE GLOSSARY ON PAGE 5. SDS Record Number Date of SDS Identity of the substance Product Description Other names/synonyms Name of the supplier Recommended uses Contact detail of the supplier. Though musk xylene is a widely-used nitromusk, little information is available on its toxicity in humans. hz at pl rb kx wx ht fs ou vm
